Kaiba notes her reaction, and soon has one of his own when he hears that year. So she knows what would've happened to Domino. He's always kept a clear gaze when thinking of the future, but now, the cascading effect of his disappearance...

He has to wonder.

"2000. Even with my best efforts and advances in medicine, I'd likely die by then...but I'm sure it'd be something to see."

He reaches up toward his neck and flips open the locket, thoughts invariably drawn back to Mokuba. His hope, his future. Surely Mokuba would die by then too, but he'd hoped to leave an impact...